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KMID : 1137820100310030234
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의공학회지
2010 Volume.31 No. 3 p.234 ~ p.239
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Development of Diagnosis Protocol for Micro-spike Biopsy Using Paraffin-based Tissue Collecting tool
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Jeong Hyo-Young
Koo Kyo-In
Lee Sang-Min
Park Ho-Soo
Hong Suk-Jun
Bang Seung-Min
Song Si-Young
Cho Dong-Il
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Abstract
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We have developed and reported several micro-spikes for minimally invasive biopsy. This paper presents a diagnosis protocol for micro-spike biopsy using paraffin-based tissue collecting tool. Using the proposed tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the biopsied tissue in a micro-spike is effectively detached. The proposed diagnosis protocol prevents the loss of tissues in a paraffin embedding and sectioning process. Hence, it is compatible with conventional histopathology without additional reagents and processes. The gastro-intestinal tissue of a pig is biopsied in an in vivo environment, and then it is detached from a micro-spike using the paraffin-based tissue collecting tool. A histopathological photomicrograph of the detached tissue is acquired with the proposed diagnosis protocol. The acquired image offers clinical quality. This result shows that the paraffin-based tissue collecting tool is applicable to the medical practice.
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KEYWORD
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micro-spike, paraffin-based tissue collecting tool, detaching tool, biopsy, diagnosis
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